E!'s late-night half-hour sensation Chelsea Lately features quick-witted commentary and a refreshing pop-culture perspective from comedian, TV personality and author Chelsea Handler.

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NEW! "The tabloids kept reporting that Angelina Jolie was going to have twin girls, but she ended up having a boy and a girl. We were clearly Punk'd. They really pulled the wool over her vagina."

Are You There, Vodka? No. 1 on Best-Seller List!

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Chelsea Lately Guests This Week

Mon., July 21

A double dose of NGTV.com's Carrie Keegan, comedian Hyla Matthews and comedian Tony Rock.

Tues., July 22

Find out what Brooke Hogan really knows, tonight! Comedian John Caparulo, comedian Jay Phillips and E!'s own Giuliana Rancic.

Wed., July 23

Madonna's brother Christopher Ciccone is here to tell all...it's kind of like the next best thing. Comedian Ben Gleib, comedian Chris Spencer and Life & Style Weekly's Rachel Zalis.

Thurs., July 24

Charo's got a new album, España Cañi to chat about! Cuchi cuchi! E!'s own Jason Kennedy, comedian Heather McDonald and comedian George Wallace.

Fri., July 25

From the groundbreaking, Emmy-nominated series Mad Men, Christina Hendricks is here. Comedian Whitney Cummings, comedian Donnell Rawlings and from TBS' My Boys, Reid Scott.